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Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer
Interleukin-6 (IL-6) is a pleiotropic cytokine with known multiple functions in immune regulation, inflammation, and oncogenesis. Binding of IL-6 to the IL-6 receptor (IL-6R) induces homodimerization and recruitment of glycoprotein 130 (gp130), which leads to activation of downstream signaling. Emer...
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| Udgivet i: | Oncotarget |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Impact Journals LLC
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4941253/ https://ncbi.nlm.nih.gov/pubmed/26840088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7102 |
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