The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation

BACKGROUND: Group 2 innate lymphoid cells (ILC2) are an important source of the type 2 cytokines interleukin (IL)-5 and IL-13 that are critical to the allergic airway phenotype. Previous studies reported that histone deacetylase (HDAC) inhibition by trichostatin A (TSA) downregulated adaptive allerg...

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Veröffentlicht in:Thorax
Hauptverfasser: Toki, Shinji, Goleniewska, Kasia, Reiss, Sara, Zhou, Weisong, Newcomb, Dawn C, Bloodworth, Melissa H, Stier, Matthew T, Boyd, Kelli L, Polosukhin, Vasiliy V, Subramaniam, Sriram, Peebles, R Stokes
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2016
Schlagworte:
Respiratory Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941189/
https://ncbi.nlm.nih.gov/pubmed/27071418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2015-207728
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