CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism

INTRODUCTION: CD248 (endosialin) is a stromal cell marker expressed on fibroblasts and pericytes. During liver injury, myofibroblasts are the main source of fibrotic matrix. OBJECTIVE: To determine the role of CD248 in the development of liver fibrosis in the rodent and human setting. DESIGN: CD248...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Wilhelm, Annika, Aldridge, Victoria, Haldar, Debashis, Naylor, Amy J, Weston, Christopher J, Hedegaard, Ditte, Garg, Abhilok, Fear, Janine, Reynolds, Gary M, Croft, Adam P, Henderson, Neil C, Buckley, Christopher D, Newsome, Philip N
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Hepatology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941145/
https://ncbi.nlm.nih.gov/pubmed/26078290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-308325
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