Genetic Deletion of the Stromal Cell Marker CD248 (Endosialin) Protects against the Development of Renal Fibrosis

BACKGROUND: Tissue fibrosis and microvascular rarefaction are hallmarks of progressive renal disease. CD248 is a transmembrane glycoprotein expressed by key effector cells within the stroma of fibrotic kidneys including pericytes, myofibroblasts and stromal fibroblasts. In human disease, increased e...

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Detalhes bibliográficos
Publicado no:Nephron Clin Pract
Main Authors: Smith, Stuart William, Croft, Adam Paul, Morris, Hannah Louise, Naylor, Amy Jane, Huso, David Leonard, Isacke, Clare Marie, Savage, Caroline Olivia Susan, Buckley, Christopher Dominic
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2016
Assuntos:
Experimental Nephrology and Genetics: Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872467/
https://ncbi.nlm.nih.gov/pubmed/26633297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000438754
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