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Calcitonin gene-related peptide contributes to peripheral nerve injury-induced mechanical hypersensitivity through CCL5 and p38 pathways

The role of calcitonin gene related peptide (CGRP) in neuropathic pain was investigated in a mouse model of neuropathic pain, spinal nerve L5 transection (L5Tx). Intrathecal injection (i.t) of CGRP(8–37,) a CGRP antagonist, significantly reduced L5Tx-induced mechanical hypersensitivity and lumbar sp...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Neuroimmunol
Main Authors: Malon, Jennifer T., Cao, Ling
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940993/
https://ncbi.nlm.nih.gov/pubmed/27397078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2016.05.003
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