Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia

BACKGROUND: Microglia are resident myeloid cells in the CNS that are activated by infection, neuronal injury, and inflammation. Established BV2 microglial cell lines have been the primary in vitro models used to study neuroinflammation for more than a decade because they reduce the requirement of co...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Das, Amitabh, Kim, Sun Hwa, Arifuzzaman, Sarder, Yoon, Taeho, Chai, Jin Choul, Lee, Young Seek, Park, Kyoung Sun, Jung, Kyoung Hwa, Chai, Young Gyu
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940985/
https://ncbi.nlm.nih.gov/pubmed/27400875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0644-1
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