RNA sequencing reveals distinct mechanisms underlying BET inhibitor JQ1-mediated modulation of the LPS-induced activation of BV-2 microglial cells

BACKGROUND: Microglial cells become rapidly activated through interaction with pathogens, and their persistent activation is associated with the production and secretion of various pro-inflammatory genes, cytokines, and chemokines, which may initiate or amplify neurodegenerative diseases. Bromodomai...

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Détails bibliographiques
Publié dans:J Neuroinflammation
Auteurs principaux: Jung, Kyoung Hwa, Das, Amitabh, Chai, Jin Choul, Kim, Sun Hwa, Morya, Nishi, Park, Kyoung Sun, Lee, Young Seek, Chai, Young Gyu
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359438/
https://ncbi.nlm.nih.gov/pubmed/25890327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0260-5
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