The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces dopamine release

BACKGROUND AND PURPOSE: Using an in‐house bioinformatics programme, we identified and synthesized a novel nonapeptide, H‐Pro‐Pro‐Thr‐Thr‐Thr‐Lys‐Phe‐Ala‐Ala‐OH. Here, we have studied its biological activity, in vitro and in vivo, and have identified its target in the brain. EXPERIMENTAL APPROACH: Th...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Neasta, Jérémie, Valmalle, Charlène, Coyne, Anne‐Claire, Carnazzi, Eric, Subra, Gilles, Galleyrand, Jean‐Claude, Gagne, Didier, M'Kadmi, Céline, Bernad, Nicole, Bergé, Gilbert, Cantel, Sonia, Marin, Philippe, Marie, Jacky, Banères, Jean‐Louis, Kemel, Marie‐Lou, Daugé, Valérie, Puget, Karine, Martinez, Jean
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940823/
https://ncbi.nlm.nih.gov/pubmed/27027724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13424
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