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On the different experimental manifestations of two‐state ‘induced‐fit’ binding of drugs to their cellular targets
‘Induced‐fit’ binding of drugs to a target may lead to high affinity, selectivity and a long residence time, and this mechanism has been proposed to apply to many drugs with high clinical efficacy. It is a multistep process that initially involves the binding of a drug to its target to form a loose...
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| Pubblicato in: | Br J Pharmacol |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4940813/ https://ncbi.nlm.nih.gov/pubmed/26808227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13445 |
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