Physiological concentrations of bile acids down‐regulate agonist induced secretion in colonic epithelial cells

In patients with bile acid malabsorption, high concentrations of bile acids enter the colon and stimulate Cl(−) and fluid secretion, thereby causing diarrhoea. However, deoxycholic acid (DCA), the predominant colonic bile acid, is normally present at lower concentrations where its role in regulating...

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Vydáno v:J Cell Mol Med
Hlavní autoři: Keating, Niamh, Mroz, Magdalena S., Scharl, Michael M., Marsh, Christine, Ferguson, Gail, Hofmann, Alan F., Keely, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2009
Témata:
Small Molecules: Molecular Bullets
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940785/
https://ncbi.nlm.nih.gov/pubmed/19583809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00838.x
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