Parkinsonism driven by antipsychotics originates from dopaminergic control of striatal cholinergic interneurons

Typical antipsychotics can cause disabling side effects. Specifically, antagonism of D2R signaling by the typical antipsychotic haloperidol induces parkinsonism in humans and catalepsy in rodents. Striatal dopamine D2 receptors (D2R) are major regulators of motor activity through their signaling on...

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Publicado en:Neuron
Autores principales: Kharkwal, Geetika, Brami-Cherrier, Karen, Lizardi-Ortiz, José E., Nelson, Alexandra B., Ramos, Maria, Del Barrio, Daniel, Sulzer, David, Kreitzer, Anatol C., Borrelli, Emiliana
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939839/
https://ncbi.nlm.nih.gov/pubmed/27387649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.06.014
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