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Parkinsonism driven by antipsychotics originates from dopaminergic control of striatal cholinergic interneurons
Typical antipsychotics can cause disabling side effects. Specifically, antagonism of D2R signaling by the typical antipsychotic haloperidol induces parkinsonism in humans and catalepsy in rodents. Striatal dopamine D2 receptors (D2R) are major regulators of motor activity through their signaling on...
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| 出版年: | Neuron |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939839/ https://ncbi.nlm.nih.gov/pubmed/27387649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.06.014 |
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