Parkinsonism driven by antipsychotics originates from dopaminergic control of striatal cholinergic interneurons

Typical antipsychotics can cause disabling side effects. Specifically, antagonism of D2R signaling by the typical antipsychotic haloperidol induces parkinsonism in humans and catalepsy in rodents. Striatal dopamine D2 receptors (D2R) are major regulators of motor activity through their signaling on...

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Bibliographic Details
Published in:Neuron
Main Authors: Kharkwal, Geetika, Brami-Cherrier, Karen, Lizardi-Ortiz, José E., Nelson, Alexandra B., Ramos, Maria, Del Barrio, Daniel, Sulzer, David, Kreitzer, Anatol C., Borrelli, Emiliana
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939839/
https://ncbi.nlm.nih.gov/pubmed/27387649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.06.014
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