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Parkinsonism driven by antipsychotics originates from dopaminergic control of striatal cholinergic interneurons

Typical antipsychotics can cause disabling side effects. Specifically, antagonism of D2R signaling by the typical antipsychotic haloperidol induces parkinsonism in humans and catalepsy in rodents. Striatal dopamine D2 receptors (D2R) are major regulators of motor activity through their signaling on...

詳細記述

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書誌詳細
出版年:Neuron
主要な著者: Kharkwal, Geetika, Brami-Cherrier, Karen, Lizardi-Ortiz, José E., Nelson, Alexandra B., Ramos, Maria, Del Barrio, Daniel, Sulzer, David, Kreitzer, Anatol C., Borrelli, Emiliana
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939839/
https://ncbi.nlm.nih.gov/pubmed/27387649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.06.014
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