Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

The catalytic activities of covalent and ATP-dependent chromatin remodeling are central to regulating the conformational state of chromatin and the resultant transcriptional output. The enzymes that catalyze these activities are often contained within multiprotein complexes in nature. Two such multi...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Kawano, Satoshi, Grassian, Alexandra R., Tsuda, Masumi, Knutson, Sarah K., Warholic, Natalie M., Kuznetsov, Galina, Xu, Shanqin, Xiao, Yonghong, Pollock, Roy M., Smith, Jesse S., Kuntz, Kevin K., Ribich, Scott, Minoshima, Yukinori, Matsui, Junji, Copeland, Robert A., Tanaka, Shinya, Keilhack, Heike
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938529/
https://ncbi.nlm.nih.gov/pubmed/27391784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158888
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