Evaluation of innate and adaptive immunity contributing to the antitumor effects of PD1 blockade in an orthotopic murine model of pancreatic cancer

Despite the clinical success of anti-PD1 antibody (α-PD1) therapy, the immune mechanisms contributing to the antineoplastic response remain unclear. Here, we describe novel aspects of the immune response involved in α-PD1-induced antitumor effects using an orthotopic Kras(G12D)/p53(R172H)/Pdx1-Cre (...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: D'Alincourt Salazar, Marcela, Manuel, Edwin R., Tsai, Weimin, D'Apuzzo, Massimo, Goldstein, Leanne, Blazar, Bruce R., Diamond, Don J.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938374/
https://ncbi.nlm.nih.gov/pubmed/27471630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1160184
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