CXCR1-mediated Neutrophil Degranulation and Fungal Killing Promotes Candida Clearance and Host Survival

Systemic Candida albicans infection causes high morbidity and mortality and is now the leading cause of nosocomial bloodstream infection in the US. Neutropenia is a major risk factor for poor outcome in infected patients; however, the molecular factors that mediate neutrophil trafficking and effecto...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Swamydas, Muthulekha, Gao, Ji-Liang, Break, Timothy J., Johnson, Melissa D., Jaeger, Martin, Rodriguez, Carlos A., Lim, Jean K., Green, Nathaniel M., Collar, Amanda L., Fischer, Brett G., Lee, Chyi-Chia Richard, Perfect, John R., Alexander, Barbara D., Kullberg, Bart-Jan, Netea, Mihai G., Murphy, Philip M., Lionakis, Michail S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938152/
https://ncbi.nlm.nih.gov/pubmed/26791948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac7718
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