Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity

BACKGROUND: The aryl hydrocarbon receptor repressor (AhRR) is known to repress aryl hydrocarbon receptor (AhR) signaling, but very little is known regarding the role of the AhRR in vivo. OBJECTIVE: This study tested the role of AhRR in vivo in AhRR overexpressing mice on molecular and toxic end poin...

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Veröffentlicht in:Environ Health Perspect
Hauptverfasser: Vogel, Christoph F.A., Chang, W.L. William, Kado, Sarah, McCulloh, Kelly, Vogel, Helena, Wu, Dalei, Haarmann-Stemmann, Thomas, Yang, GuoXiang, Leung, Patrick S.C., Matsumura, Fumio, Gershwin, M. Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Institute of Environmental Health Sciences 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937866/
https://ncbi.nlm.nih.gov/pubmed/26862745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1510194
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