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Effect of the CYP3A inhibitors, diltiazem and ketoconazole, on ticagrelor pharmacokinetics in healthy volunteers

OBJECTIVES: Two open-label, two-period, crossover studies in healthy volunteers were designed to determine the pharmacokinetic interactions between ticagrelor, a P2Y(12) receptor antagonist, and a moderate (diltiazem) and a strong (ketoconazole) cytochrome P450 (CYP) 3A inhibitor. METHODS: Seventeen...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Drug Assess
Prif Awduron: Teng, Renli, Butler, Kathleen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Maney Publishing 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937655/
https://ncbi.nlm.nih.gov/pubmed/27536435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/21556660.2013.785413
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