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Basset: learning the regulatory code of the accessible genome with deep convolutional neural networks

The complex language of eukaryotic gene expression remains incompletely understood. Despite the importance suggested by many noncoding variants statistically associated with human disease, nearly all such variants have unknown mechanisms. Here, we address this challenge using an approach based on a...

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Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: Kelley, David R., Snoek, Jasper, Rinn, John L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937568/
https://ncbi.nlm.nih.gov/pubmed/27197224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.200535.115
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