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Heterozygote Advantage Is a Common Outcome of Adaptation in Saccharomyces cerevisiae

Adaptation in diploids is predicted to proceed via mutations that are at least partially dominant in fitness. Recently, we argued that many adaptive mutations might also be commonly overdominant in fitness. Natural (directional) selection acting on overdominant mutations should drive them into the p...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Sellis, Diamantis, Kvitek, Daniel J., Dunn, Barbara, Sherlock, Gavin, Petrov, Dmitri A.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937471/
https://ncbi.nlm.nih.gov/pubmed/27194750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.185165
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