Transcriptional reprogramming of metabolic pathways in critically ill patients

BACKGROUND: Critical illness causes a shift away from mitochondrial metabolism towards a greater dependence on glycolysis. This metabolic shift is thought to be associated with lactic acidosis, organ dysfunction and poor clinical outcomes. The current paradigm is that low oxygen supply causes region...

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Bibliographic Details
Published in:Intensive Care Med Exp
Main Authors: Nalos, Marek, Parnell, Grant, Robergs, Robert, Booth, David, McLean, Anthony S., Tang, Benjamin M.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936987/
https://ncbi.nlm.nih.gov/pubmed/27387528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-016-0094-1
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