Somatic alterations of CDKN1B are associated with small bowel neuroendocrine tumors

CDKN1B , a cyclin-dependent kinase inhibitor associated with G1 arrest, was recently proposed as an important tumor suppressor gene in small bowel neuroendocrine tumors (SBNETs). The rate of frameshift mutations in SBNET primaries are reportedly 7.4%, and hemizygous deletions are 6.7%. We set out to...

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Vydáno v:Cancer Genet
Hlavní autoři: Maxwell, Jessica E., Sherman, Scott K., Li, Guiying, Choi, Allen B., Bellizzi, Andrew M., O’Dorisio, Thomas M., Howe, James R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936963/
https://ncbi.nlm.nih.gov/pubmed/26603463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergen.2015.08.003
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