Somatic alterations of CDKN1B are associated with small bowel neuroendocrine tumors

CDKN1B , a cyclin-dependent kinase inhibitor associated with G1 arrest, was recently proposed as an important tumor suppressor gene in small bowel neuroendocrine tumors (SBNETs). The rate of frameshift mutations in SBNET primaries are reportedly 7.4%, and hemizygous deletions are 6.7%. We set out to...

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發表在:Cancer Genet
Main Authors: Maxwell, Jessica E., Sherman, Scott K., Li, Guiying, Choi, Allen B., Bellizzi, Andrew M., O’Dorisio, Thomas M., Howe, James R.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936963/
https://ncbi.nlm.nih.gov/pubmed/26603463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergen.2015.08.003
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