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Cyclin-dependent Kinase 11 (CDK11) is Required for Ovarian Cancer Cell Growth in vitro and in vivo, and its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel

Ovarian cancer is currently the most lethal gynecological malignancy with limited treatment options. Improved targeted therapies are needed to combat ovarian cancer. Here, we report the identification of cyclin-dependent kinase 11 (CDK11) as a mediator of tumor cell growth and proliferation in ovari...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Liu, Xianzhe, Gao, Yan, Shen, Jacson, Yang, Wen, Choy, Edwin, Mankin, Henry, Hornicek, Francis J., Duan, Zhenfeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936930/
https://ncbi.nlm.nih.gov/pubmed/27207777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0032
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