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The Treponema denticola FhbB Protein Is a Dominant Early Antigen That Elicits FhbB Variant-Specific Antibodies That Block Factor H Binding and Cleavage by Dentilisin

The Treponema denticola FhbB protein contributes to immune evasion by binding factor H (FH). Cleavage of FH by the T. denticola protease, dentilisin, may contribute to the local immune dysregulation that is characteristic of periodontal disease (PD). Although three FhbB phyletic types have been defi...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Miller, Daniel P., Oliver, Lee D., Tegels, Brittney K., Reed, Lucas A., O'Bier, Nathaniel S., Kurniyati, Kurni, Faust, Lindsay A., Lawson, Christine K., Allard, Anna M., Caimano, Melissa J., Marconi, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936362/
https://ncbi.nlm.nih.gov/pubmed/27113359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01542-15
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