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Interactive Organization of the Circadian Core Regulators PER2, BMAL1, CLOCK and PML

The BMAL1 and CLOCK heterodimer in the mammalian circadian transcriptional complex is thought to be repressed by PER2 and CRY1 via direct interactions. We recently reported that PER2 is largely cytosolic in Pml(−/−) cells and did not co-immunoprecipitate (co-IP) with BMAL1 or CLOCK. Here, using mult...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Miki, Takao, Zhao, Zhaoyang, Lee, Cheng Chi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935866/
https://ncbi.nlm.nih.gov/pubmed/27383066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29174
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