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Proximal tubule-specific glutamine synthetase deletion alters basal and acidosis-stimulated ammonia metabolism
Glutamine synthetase (GS) catalyzes the recycling of NH(4)(+) with glutamate to form glutamine. GS is highly expressed in the renal proximal tubule (PT), suggesting ammonia recycling via GS could decrease net ammoniagenesis and thereby limit ammonia available for net acid excretion. The purpose of t...
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| Veröffentlicht in: | Am J Physiol Renal Physiol |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4935770/ https://ncbi.nlm.nih.gov/pubmed/27009341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00547.2015 |
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