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The lupus susceptibility gene Pbx1 regulates the balance between follicular helper T cell and regulatory T cell differentiation
Pbx1 controls chromatin accessibility to a large number of genes and is entirely conserved between mice and humans. The Pbx1-d dominant negative isoform is more frequent in the CD4(+) T cells from lupus patients than from healthy controls. Pbx1-d is associated with the production of autoreactive T c...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4935607/ https://ncbi.nlm.nih.gov/pubmed/27296664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502283 |
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