Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells

Follicular helper T (T(FH)) cells are expanded in systemic lupus erythematosus, where they are required to produce high affinity autoantibodies. Eliminating T(FH) cells would, however compromise the production of protective antibodies against viral and bacterial pathogens. Here we show that inhibiti...

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Publicado en:Nat Commun
Autores principales: Choi, Seung-Chul, Titov, Anton A., Abboud, Georges, Seay, Howard R., Brusko, Todd M., Roopenian, Derry C., Salek-Ardakani, Shahram, Morel, Laurence
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197193/
https://ncbi.nlm.nih.gov/pubmed/30348969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06686-0
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