Constitutive Lck activity drives sensitivity differences between CD8+ memory T cell subsets

CD8+ T cells develop increased sensitivity following antigen experience, and differences in sensitivity exist between T cell memory subsets. How differential TCR signaling between memory subsets contributes to sensitivity differences is unclear. We show in mouse effector memory T cells (T(EM)) that...

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Veröffentlicht in:J Immunol
Hauptverfasser: Moogk, Duane, Zhong, Shi, Yu, Zhiya, Liadi, Ivan, Rittase, William, Fang, Victoria, Dougherty, Janna, Perez-Garcia, Arianne, Osman, Iman, Zhu, Cheng, Varadarajan, Navin, Restifo, Nicholas P., Frey, Alan B., Krogsgaard, Michelle
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935560/
https://ncbi.nlm.nih.gov/pubmed/27271569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600178
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