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Keratin 8 knockdown leads to loss of the chloride transporter DRA in the colon

Keratins (K) are intermediate filament proteins important in protection from stress. The roles of keratins in the intestine are not clear, but K8 knockout (K8(−/−)) mice develop a Th2-type colonic inflammation, epithelial hyperproliferation, and mild diarrhea caused by a keratin level-dependent decr...

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Dades bibliogràfiques
Publicat a:Am J Physiol Gastrointest Liver Physiol
Autors principals: Asghar, M. Nadeem, Priyamvada, Shubha, Nyström, Joel H., Anbazhagan, Arivarasu Natarajan, Dudeja, Pradeep K., Toivola, Diana M.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935477/
https://ncbi.nlm.nih.gov/pubmed/27125276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00354.2015
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