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Alteration of WWOX in human cancer, a clinical view

WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. Its tumor suppressor activity has been proposed on a basis of numerous genomic alterations reported in chromosome 16q23.3–24.1 locus. WWOX is affected in many cancers, showing as high as 80% loss of heterozygosity in breas...

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Dettagli Bibliografici
Pubblicato in:Exp Biol Med (Maywood)
Autori principali: Baryła, Izabela, Styczeń-Binkowska, Ewa, Bednarek, Andrzej K
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935223/
https://ncbi.nlm.nih.gov/pubmed/25681467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370214561953
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