Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1

We previously proposed that hyperglycemia-induced mitochondrial reactive oxygen species (mtROS) generation is a key event in the development of diabetic complications. Interestingly, some common aspects exist between hyperglycemia and hypoxia-induced phenomena. Thus, hyperglycemia may induce cellula...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sada, Kiminori, Nishikawa, Takeshi, Kukidome, Daisuke, Yoshinaga, Tomoaki, Kajihara, Nobuhiro, Sonoda, Kazuhiro, Senokuchi, Takafumi, Motoshima, Hiroyuki, Matsumura, Takeshi, Araki, Eiichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934928/
https://ncbi.nlm.nih.gov/pubmed/27383386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158619
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