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An Ugi Reaction Incorporating a Redox-Neutral Amine C–H Functionalization Step

Pyrrolidine and 1,2,3,4-tetrahydroisoquinoline (THIQ) undergo redox-neutral α-amidation with concurrent N-alkylation upon reaction with aromatic aldehydes and isocyanides. Reactions are promoted by acetic acid and represent a new variant of the Ugi-reaction.

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Bibliografiske detaljer
Udgivet i:Org Lett
Main Authors: Zhu, Zhengbo, Seidel, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934885/
https://ncbi.nlm.nih.gov/pubmed/26785064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.5b03529
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