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An Ugi Reaction Incorporating a Redox-Neutral Amine C–H Functionalization Step
Pyrrolidine and 1,2,3,4-tetrahydroisoquinoline (THIQ) undergo redox-neutral α-amidation with concurrent N-alkylation upon reaction with aromatic aldehydes and isocyanides. Reactions are promoted by acetic acid and represent a new variant of the Ugi-reaction.
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| Udgivet i: | Org Lett |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4934885/ https://ncbi.nlm.nih.gov/pubmed/26785064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.5b03529 |
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