Metabolism, Protein Binding, and Renal Clearance of Microbiota–Derived p-Cresol in Patients with CKD

BACKGROUND AND OBJECTIVES: Colonic microbial metabolism substantially contributes to uremic retention solutes in CKD. p-Cresyl sulfate is the main representative of this group of solutes, relating to adverse outcomes. Other than sulfate conjugation, p-cresol is subjected to endogenous glucuronide co...

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Bibliografiske detaljer
Udgivet i:Clin J Am Soc Nephrol
Main Authors: Poesen, Ruben, Evenepoel, Pieter, de Loor, Henriette, Kuypers, Dirk, Augustijns, Patrick, Meijers, Björn
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2016
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934829/
https://ncbi.nlm.nih.gov/pubmed/27084876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2215/CJN.00160116
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