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Quantification of designer nuclease induced mutation rates: a direct comparison of different methods
Designer nucleases are broadly applied to induce site-specific DNA double-strand breaks (DSB) in genomic DNA. These are repaired by nonhomologous end joining leading to insertions or deletions (in/dels) at the respective DNA-locus. To detect in/del mutations, the heteroduplex based T7-endonuclease I...
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| Vydáno v: | Mol Ther Methods Clin Dev |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4934480/ https://ncbi.nlm.nih.gov/pubmed/27419195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.47 |
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