A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

The high-grade pulmonary neuroendocrine tumors, small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC), remain among the most deadly malignancies. Therapies that effectively target and kill tumor-initiating cells (TICs) in these cancers should translate to improved patient sur...

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Bibliografiska uppgifter
I publikationen:Sci Transl Med
Huvudupphovsmän: Saunders, Laura R., Bankovich, Alexander J., Anderson, Wade C., Aujay, Monette A., Bheddah, Sheila, Black, KristenAnn, Desai, Radhika, Escarpe, Paul A., Hampl, Johannes, Laysang, Amy, Liu, David, Lopez-Molina, Javier, Milton, Milly, Park, Albert, Pysz, Marybeth A., Shao, Hui, Slingerland, Brian, Torgov, Michael, Williams, Samuel A., Foord, Orit, Howard, Philip, Jassem, Jacek, Badzio, Andrzej, Czapiewski, Piotr, Harpole, David H., Dowlati, Afshin, Massion, Pierre P., Travis, William D., Pietanza, M. Catherine, Poirier, J. T., Rudin, Charles M., Stull, Robert A., Dylla, Scott J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934375/
https://ncbi.nlm.nih.gov/pubmed/26311731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac9459
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