A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

The high-grade pulmonary neuroendocrine tumors, small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC), remain among the most deadly malignancies. Therapies that effectively target and kill tumor-initiating cells (TICs) in these cancers should translate to improved patient sur...

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Publicado no:Sci Transl Med
Main Authors: Saunders, Laura R., Bankovich, Alexander J., Anderson, Wade C., Aujay, Monette A., Bheddah, Sheila, Black, KristenAnn, Desai, Radhika, Escarpe, Paul A., Hampl, Johannes, Laysang, Amy, Liu, David, Lopez-Molina, Javier, Milton, Milly, Park, Albert, Pysz, Marybeth A., Shao, Hui, Slingerland, Brian, Torgov, Michael, Williams, Samuel A., Foord, Orit, Howard, Philip, Jassem, Jacek, Badzio, Andrzej, Czapiewski, Piotr, Harpole, David H., Dowlati, Afshin, Massion, Pierre P., Travis, William D., Pietanza, M. Catherine, Poirier, J. T., Rudin, Charles M., Stull, Robert A., Dylla, Scott J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934375/
https://ncbi.nlm.nih.gov/pubmed/26311731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac9459
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