Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

BACKGROUND: The success of the CRISPR/Cas9 genome editing technique depends on the choice of the guide RNA sequence, which is facilitated by various websites. Despite the importance and popularity of these algorithms, it is unclear to which extent their predictions are in agreement with actual measu...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Haeussler, Maximilian, Schönig, Kai, Eckert, Hélène, Eschstruth, Alexis, Mianné, Joffrey, Renaud, Jean-Baptiste, Schneider-Maunoury, Sylvie, Shkumatava, Alena, Teboul, Lydia, Kent, Jim, Joly, Jean-Stephane, Concordet, Jean-Paul
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934014/
https://ncbi.nlm.nih.gov/pubmed/27380939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1012-2
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