Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway

Hyperglycemia upregulates thioredoxin interacting protein (TXNIP) expression, which in turn induces ROS production, inflammatory and fibrotic responses in the diabetic kidney. Dysregulation of autophagy contributes to the development of diabetic nephropathy. However, the interaction of TXNIP with au...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Huang, Chunling, Zhang, Yuan, Kelly, Darren J., Tan, Christina Y. R., Gill, Anthony, Cheng, Delfine, Braet, Filip, Park, Jin-Sung, Sue, Carolyn M., Pollock, Carol A., Chen, Xin-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933928/
https://ncbi.nlm.nih.gov/pubmed/27381856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29196
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados