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Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition

Innovative strategies are necessary to maximize the clinical application of HIV neutralizing antibodies. To this end, bispecific constructs of human antibody F240, reactive with well-conserved gp41 epitope and antibody 14A8, reactive with the IgA receptor (CD89) on effector cells, were constructed....

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Foilsithe in:J Immunol Res
Main Authors: Yu, Xiaocong, Duval, Mark, Gawron, Melissa, Posner, Marshall R., Cavacini, Lisa A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Hindawi Publishing Corporation 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933884/
https://ncbi.nlm.nih.gov/pubmed/27419146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9425172
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