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A Bispecific Antibody Composed of a Nonneutralizing Antibody to the gp41 Immunodominant Region and an Anti-CD89 Antibody Directs Broad Human Immunodeficiency Virus Destruction by Neutrophils

In addition to the direct neutralization of virus, there is a broader potential for antibody-mediated inhibition of human immunodeficiency virus (HIV) by targeting HIV to effector cells. We demonstrate here that a bispecific antibody incorporating a broadly reactive anti-gp41 antibody, F240, and an...

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Bibliografske podrobnosti
Main Authors: Duval, Mark, Posner, Marshall R., Cavacini, Lisa A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293036/
https://ncbi.nlm.nih.gov/pubmed/18272577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02499-07
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