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T cells expressing CD19/CD20 bi-specific chimeric antigen receptors prevent antigen escape by malignant B cells

The adoptive transfer of T cells expressing anti-CD19 chimeric antigen receptors (CARs) has shown remarkable curative potential against advanced B-cell malignancies, but multiple trials have also reported patient relapses due to the emergence of CD19-negative leukemic cells. Here, we report the desi...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Zah, Eugenia, Lin, Meng-Yin, Silva-Benedict, Anne, Jensen, Michael C., Chen, Yvonne Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933590/
https://ncbi.nlm.nih.gov/pubmed/27059623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0231
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