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Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments

γ-Secretase complexes achieve the production of amyloid peptides playing a key role in Alzheimer disease. These proteases have many substrates involved in important physiological functions. They are composed of two constant subunits, nicastrin and PEN2, and two variable ones, presenilin (PS1 or PS2)...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Meckler, Xavier, Checler, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933450/
https://ncbi.nlm.nih.gov/pubmed/27059953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708297
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