Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats

BACKGROUND: The platelet-derived growth factor receptor β (PDGFRβ)+ perivascular cell activation becomes increasingly recognized as a main source of scar-associated kidney myofibroblasts and recently emerged as a new cellular therapeutic target. AIMS: In this regard, we first confirmed the presence...

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Publicat a:PLoS One
Autors principals: Pozdzik, Agnieszka A., Giordano, Laetitia, Li, Gang, Antoine, Marie-Hélène, Quellard, Nathalie, Godet, Julie, De Prez, Eric, Husson, Cécile, Declèves, Anne-Emilie, Arlt, Volker M., Goujon, Jean-Michel, Brochériou-Spelle, Isabelle, Ledbetter, Steven R., Caron, Nathalie, Nortier, Joëlle L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933370/
https://ncbi.nlm.nih.gov/pubmed/27379382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157288
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