The Molecular Chaperone GRP78 Contributes to Toll-like Receptor 3-mediated Innate Immune Response to Hepatitis C Virus in Hepatocytes

Toll-like receptor-3 (TLR3) senses double-stranded RNA intermediates produced during hepatitis C virus (HCV) replication, leading to activation of interferon regulatory factor-3 (IRF3) and NF-κB and subsequent antiviral and proinflammatory responses. Yet, how this TLR3-dependent pathway operates in...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wei, Dahai, Li, Nan L., Zeng, Yanli, Liu, Baoming, Kumthip, Kattareeya, Wang, Tony T., Huo, Dezheng, Ingels, Jesse F., Lu, Lu, Shang, Jia, Li, Kui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933277/
https://ncbi.nlm.nih.gov/pubmed/27129228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.711598
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