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Exosome Cofactors Connect Transcription Termination to RNA Processing by Guiding Terminated Transcripts to the Appropriate Exonuclease within the Nuclear Exosome

The yeast Nrd1 interacts with the C-terminal domain (CTD) of RNA polymerase II (RNApII) through its CTD-interacting domain (CID) and also associates with the nuclear exosome, thereby acting as both a transcription termination and RNA processing factor. Previously, we found that the Nrd1 CID is requi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kim, Kyumin, Heo, Dong-hyuk, Kim, Iktae, Suh, Jeong-Yong, Kim, Minkyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933236/
https://ncbi.nlm.nih.gov/pubmed/27076633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.715771
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