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Competitive Inhibition of Lysine Acetyltransferase 2B by a Small Motif of the Adenoviral Oncoprotein E1A

The adenovirus early region 1A (E1A) oncoprotein hijacks host cells via direct interactions with many key cellular proteins, such as KAT2B, also known as PCAF (p300/CBP associated factor). E1A binds the histone acetyltransferase (HAT) domain of KAT2B to repress its transcriptional activation. Howeve...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Shi, Shasha, Liu, Ke, Chen, Yanheng, Zhang, Shijun, Lin, Juanyu, Gong, Chenfang, Jin, Quanwen, Yang, Xiang-Jiao, Chen, Ruichuan, Ji, Zhiliang, Han, Aidong
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933189/
https://ncbi.nlm.nih.gov/pubmed/27143356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.697300
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