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Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain

Copper is an essential metal ion for embryonic development, iron acquisition, cardiac function, neuropeptide biogenesis, and other critical physiological processes. Ctr1 is a high affinity Cu(+) transporter on the plasma membrane and endosomes that exists as a full-length protein and a truncated for...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Öhrvik, Helena, Logeman, Brandon, Turk, Boris, Reinheckel, Thomas, Thiele, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933151/
https://ncbi.nlm.nih.gov/pubmed/27143361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731281
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