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Single-Molecule Force Spectroscopy Studies of APOBEC3A–Single-Stranded DNA Complexes

APOBEC3A (A3A) inhibits the replication of a range of viruses and transposons and might also play a role in carcinogenesis. It is a single-domain deaminase enzyme that interacts with single-stranded DNA (ssDNA) and converts cytidines to uridines within specific trinucleotide contexts. Although there...

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Udgivet i:Biochemistry
Main Authors: Shlyakhtenko, Luda S., Dutta, Samrat, Li, Ming, Harris, Reuben S., Lyubchenko, Yuri L.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932870/
https://ncbi.nlm.nih.gov/pubmed/27182892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00214
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