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Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Patients with Recurrent/Progressive Glioblastoma Multiforme, Anaplastic Astrocytoma, or Gliosarcoma

M032 is a second-generation oncolytic herpes simplex virus (oHSV) that selectively replicates in tumor cells. M032 kills tumor cells directly through oncolytic replication and then proceeds to infect tumor cells in proximity, continuing the process of tumor destruction. In addition to this direct on...

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Podrobná bibliografie
Vydáno v:Hum Gene Ther Clin Dev
Hlavní autoři: Patel, Daxa M., Foreman, Paul M., Nabors, L. Burt, Riley, Kristen O., Gillespie, G. Yancey, Markert, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932657/
https://ncbi.nlm.nih.gov/pubmed/27314913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2016.031
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