Silica-coated magnetic nanoparticles impair proteasome activity and increase the formation of cytoplasmic inclusion bodies in vitro

The potential toxicity of nanoparticles, particularly to neurons, is a major concern. In this study, we assessed the cytotoxicity of silica-coated magnetic nanoparticles containing rhodamine B isothiocyanate dye (MNPs@SiO(2)(RITC)) in HEK293 cells, SH-SY5Y cells, and rat primary cortical and dopamin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Phukan, Geetika, Shin, Tae Hwan, Shim, Jeom Soon, Paik, Man Jeong, Lee, Jin-Kyu, Choi, Sangdun, Kim, Yong Man, Kang, Seong Ho, Kim, Hyung Sik, Kang, Yup, Lee, Soo Hwan, Mouradian, M. Maral, Lee, Gwang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932509/
https://ncbi.nlm.nih.gov/pubmed/27378605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29095
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